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	<title>iFATS</title>
	<link>http://ifats.org</link>
	<description>Just another WordPress weblog</description>
	<lastBuildDate>Sat, 04 Sep 2010 08:16:01 +0000</lastBuildDate>
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		<title>Adipocyte-derived factors suppress heart contraction.</title>
		<description><![CDATA[Background:Obesity is strongly associated with cardiovascular diseases including  systemic hypertension, coronary artery disease and heart failure. Despite several investigations the pathophysiological mechanisms involved remain unclear. We have previously shown that adipose tissue exerts a highly potent activity with an acute depressant effect on cardiomyocytes, thus suggesting direct involvement of  adipose tissue in the development of [...]]]></description>
		<link>http://ifats.org/2010/09/04/adipocyte-derived-factors-suppress-heart-contraction/</link>
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		<title>Differentiation of human multipotent dermal fibroblasts into islet-like cell clusters.</title>
		<description><![CDATA[BACKGROUND: We have previously obtained a clonal population of cells from human foreskin that is able to differentiate into mesodermal, ectodermal and endodermal progenies. It is of great interest to know whether these cells could be further differentiated into functional insulin-producing cells. RESULTS: Sixty-one single-cell-derived dermal fibroblast clones were established from human foreskin by limiting [...]]]></description>
		<link>http://ifats.org/2010/09/04/differentiation-of-human-multipotent-dermal-fibroblasts-into-islet-like-cell-clusters/</link>
			</item>
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		<title>Geometric control of human stem cell morphology and differentiation.</title>
		<description><![CDATA[ During tissue morphogenesis, stem cells and progenitor cells migrate, proliferate, and differentiate, with striking changes in cell shape, size, and acting mechanical stresses. The local cellular function depends on the spatial distribution of cytokines as well as local mechanical microenvironments in which  the cells reside. In this study, we controlled the organization of human adipose  [...]]]></description>
		<link>http://ifats.org/2010/09/04/geometric-control-of-human-stem-cell-morphology-and-differentiation/</link>
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		<title>Simple Modular Bioreactors for Tissue Engineering: A System for Characterization  of Oxygen Gradients, Human Mesenchymal Stem Cell Differentiation, and Prevascularization.</title>
		<description><![CDATA[Large-scale tissue engineering is limited by nutrient perfusion and mass transport limitations, especially oxygen diffusion, which restrict construct development to smaller than clinically relevant dimensions and limit the ability  for in vivo integration. The goal of this work was to develop a modular approach  to tissue engineering, where scaffold and tissue size, transport issues, and [...]]]></description>
		<link>http://ifats.org/2010/09/03/simple-modular-bioreactors-for-tissue-engineering-a-system-for-characterization-of-oxygen-gradients-human-mesenchymal-stem-cell-differentiation-and-prevascularization/</link>
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		<title>Growth and Differentiation Properties of Mesenchymal Stromal Cell Populations Derived from Whole Human Umbilical Cord.</title>
		<description><![CDATA[Up to 2.8 x 10(7) fibroblast-like cells displaying an abundant presence of mesenchymal stem cell (MSC) markers CD73, CD90, CD105 and a low level of HLA-I expression can be isolated from one whole human umbilical cord (UC) using a simple and highly reproducible explant culture approach. Cells derived from whole UC, similar to cells collected [...]]]></description>
		<link>http://ifats.org/2010/09/03/growth-and-differentiation-properties-of-mesenchymal-stromal-cell-populations-derived-from-whole-human-umbilical-cord/</link>
			</item>
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		<title>A Subset of Osteoblasts Expressing High Endogenous Levels of PPARgamma Switches Fate to Adipocytes in the Rat Calvaria Cell Culture Model.</title>
		<description><![CDATA[BACKGROUND: Understanding fate choice and fate switching between the osteoblast lineage (ObL) and adipocyte lineage (AdL) is important to understand both the developmental inter-relationships between osteoblasts and adipocytes and the impact of changes in fate allocation between the two lineages in normal aging and certain diseases. The goal of this study was to determine when [...]]]></description>
		<link>http://ifats.org/2010/09/03/a-subset-of-osteoblasts-expressing-high-endogenous-levels-of-ppargamma-switches-fate-to-adipocytes-in-the-rat-calvaria-cell-culture-model/</link>
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		<title>Id4, a new candidate gene for senile osteoporosis, acts as a molecular switch promoting osteoblast differentiation.</title>
		<description><![CDATA[Excessive accumulation of bone marrow adipocytes observed in senile osteoporosis  or age-related osteopenia is caused by the unbalanced differentiation of MSCs into bone marrow adipocytes or osteoblasts. Several transcription factors are known to regulate the balance between adipocyte and osteoblast differentiation. However, the molecular mechanisms that regulate the balance between adipocyte and osteoblast differentiation in [...]]]></description>
		<link>http://ifats.org/2010/09/02/id4-a-new-candidate-gene-for-senile-osteoporosis-acts-as-a-molecular-switch-promoting-osteoblast-differentiation/</link>
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		<title>Tissue engineering and the use of stem/progenitor cells for airway epithelium repair.</title>
		<description><![CDATA[Stem/progenitor cells can be used to repair defects in the airway wall, resulting from e.g., tumors, trauma, tissue reactions following long-time intubations, or diseases that are associated with epithelial damage. Several potential sources of cells for airway epithelium have been identified. These can be divided into two groups. The first group consists of endogenous progenitor [...]]]></description>
		<link>http://ifats.org/2010/09/02/tissue-engineering-and-the-use-of-stemprogenitor-cells-for-airway-epithelium-repair/</link>
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		<title>Ochratoxin A inhibits adipogenesis through the ERK-PPAR-gamma pathway in human adipose tissue-derived mesenchymal stem cells.</title>
		<description><![CDATA[chratoxin A (OTA) is a ubiquitous fungal metabolite with nephrotoxic, carcinogenic and apoptotic potential. Although the toxic effects of OTA in various cell types are well characterized, it is not known whether OTA has an effect on stem cell differentiation. In this study, we demonstrate that OTA inhibits adipogenesis in human adipose tissue-derived mesenchymal stem [...]]]></description>
		<link>http://ifats.org/2010/09/02/ochratoxin-a-inhibits-adipogenesis-through-the-erk-ppar-gamma-pathway-in-human-adipose-tissue-derived-mesenchymal-stem-cells/</link>
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		<title>Isolating adipose-derived mesenchymal stem cells from lipoaspirate blood and saline fraction.</title>
		<description><![CDATA[Isolation of adipose-derived stem cells (ASCs) typically involves 8+ hours of intense effort, requiring specialized equipment and reagents. Here, we present an improved technique for isolating viable populations of mesenchymal stem cells from lipoaspirate saline fractions within 30 minutes. Importantly, the cells exhibit remarkable similarities to those obtained using the traditional isolation protocols, in terms [...]]]></description>
		<link>http://ifats.org/2010/09/01/isolating-adipose-derived-mesenchymal-stem-cells-from-lipoaspirate-blood-and-saline-fraction/</link>
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